Obscurin-like 1, OBSL1, is a novel cytoskeletal protein related to obscurin.

ABSTRACT: Cytoskeletal adaptor proteins serve vital functions in linking the internal cytoskeleton of cells to the cell membrane, particularly at sites of cell-cell and cell-matrix interactions. The importance of these adaptors to the structural integrity of the cell is evident from the number of clinical disease states attributable to defects in these networks. In the heart, defects in the cytoskeletal support system that surrounds and supports the myofibril result in dilated cardiomyopathy and congestive heart failure. In this study, we report the cloning and characterization of a novel cytoskeletal adaptor, obscurin-like 1 (OBSL1), which is closely related to obscurin, a giant structural protein required for sarcomere assembly. Multiple isoforms arise from alternative splicing, ranging in predict

SUBMITTER: Geisler SB 

PROVIDER: S-EPMC1885211 | biostudies-literature | 2007 Apr

REPOSITORIES: biostudies-literature