The LOC387715 polymorphism and age-related macular degeneration: replication in three case-control samples.

ABSTRACT:

Purpose

Age-related macular degeneration (AMD) is a multifactorial blinding disease in the elderly. LOC387715 harbors a single-nucleotide polymorphism that has an association with AMD. This study was conducted to confirm the association between LOC387715 and AMD and to refine estimates of the impact of this gene variation in using samples from three studies: an Australian population-based study and two U.S. clinic-based case-control studies.

Methods

Cases and controls were collected from a National Eye Institute (NEI) clinical protocol (n = 240), the Age-Related Eye Disease Study (AREDS; n = 488), and the Blue Mountains Eye Study (BMES; n = 851). After DNA extraction, subjects were genotyped for the LOC387715 Ala69Ser polymorphism (rs10490924).

Results

The combined NE

SUBMITTER: Ross RJ 

PROVIDER: S-EPMC1885234 | biostudies-literature | 2007 Mar

REPOSITORIES: biostudies-literature