Live imaging of Drosophila gonad formation reveals roles for Six4 in regulating germline and somatic cell migration.

ABSTRACT:

Background

Movement of cells, either as amoeboid individuals or in organised groups, is a key feature of organ formation. Both modes of migration occur during Drosophila embryonic gonad development, which therefore provides a paradigm for understanding the contribution of these processes to organ morphogenesis. Gonads of Drosophila are formed from three distinct cell types: primordial germ cells (PGCs), somatic gonadal precursors (SGPs), and in males, male-specific somatic gonadal precursors (msSGPs). These originate in distinct locations and migrate to associate in two intermingled clusters which then compact to form the spherical primitive gonads. PGC movements are well studied, but much less is known of the migratory events and other interactions undergone by their somatic partn

SUBMITTER: Clark IB 

PROVIDER: S-EPMC1885258 | biostudies-literature | 2007 May

REPOSITORIES: biostudies-literature