Cell surface receptors for signal transduction and ligand transport: a design principles study.

ABSTRACT: Receptors constitute the interface of cells to their external environment. These molecules bind specific ligands involved in multiple processes, such as signal transduction and nutrient transport. Although a variety of cell surface receptors undergo endocytosis, the systems-level design principles that govern the evolution of receptor trafficking dynamics are far from fully understood. We have constructed a generalized mathematical model of receptor-ligand binding and internalization to understand how receptor internalization dynamics encodes receptor function and regulation. A given signaling or transport receptor system represents a particular implementation of this module with a specific set of kinetic parameters. Parametric analysis of the response of receptor systems to ligand inputs

SUBMITTER: Shankaran H 

PROVIDER: S-EPMC1885276 | biostudies-literature | 2007 Jun

REPOSITORIES: biostudies-literature