Improvement and decline of cognitive function in schizophrenia over one year: a longitudinal investigation using latent growth modelling.

ABSTRACT:

Background

Long-term follow-up studies of people with schizophrenia report stability of cognitive performance; less is known about any shorter-term changes in cognitive function.

Methods

This longitudinal study aimed to establish whether there was stability, improvement or decline in memory and executive functions over four assessments undertaken prospectively in one year. Cognitive performance was assessed during randomized controlled trials of first- and second-generation antipsychotic medication. Analyses used a latent growth modeling approach, so that individuals who missed some testing occasions could be included and trajectories of cognitive change explored despite missing data.

Results

Over the year there was significant decline in spatial recognition but no ch

SUBMITTER: Barnett JH 

PROVIDER: S-EPMC1885799 | biostudies-literature | 2007 May

REPOSITORIES: biostudies-literature