Reconstruction of human protein interolog network using evolutionary conserved network.

ABSTRACT:

Background

The recent increase in the use of high-throughput two-hybrid analysis has generated large quantities of data on protein interactions. Specifically, the availability of information about experimental protein-protein interactions and other protein features on the Internet enables human protein-protein interactions to be computationally predicted from co-evolution events (interolog). This study also considers other protein interaction features, including sub-cellular localization, tissue-specificity, the cell-cycle stage and domain-domain combination. Computational methods need to be developed to integrate these heterogeneous biological data to facilitate the maximum accuracy of the human protein interaction prediction.

Results

This study proposes a relative conserva

SUBMITTER: Huang TW 

PROVIDER: S-EPMC1885812 | biostudies-literature | 2007 May

REPOSITORIES: biostudies-literature