NeuroConstruct: a tool for modeling networks of neurons in 3D space.

ABSTRACT: Conductance-based neuronal network models can help us understand how synaptic and cellular mechanisms underlie brain function. However, these complex models are difficult to develop and are inaccessible to most neuroscientists. Moreover, even the most biologically realistic network models disregard many 3D anatomical features of the brain. Here, we describe a new software application, neuroConstruct, that facilitates the creation, visualization, and analysis of networks of multicompartmental neurons in 3D space. A graphical user interface allows model generation and modification without programming. Models within neuroConstruct are based on new simulator-independent NeuroML standards, allowing automatic generation of code for NEURON or GENESIS simulators. neuroConstruct was tested by repro

SUBMITTER: Gleeson P 

PROVIDER: S-EPMC1885959 | biostudies-literature | 2007 Apr

REPOSITORIES: biostudies-literature