STATc is a key regulator of the transcriptional response to hyperosmotic shock.

ABSTRACT:

Background

Dictyostelium discoideum is frequently subjected to environmental changes in its natural habitat, the forest soil. In order to survive, the organism had to develop effective mechanisms to sense and respond to such changes. When cells are faced with a hypertonic environment a complex response is triggered. It starts with signal sensing and transduction and leads to changes in cell shape, the cytoskeleton, transport processes, metabolism and gene expression. Certain aspects of the Dictyostelium osmotic stress response have been elucidated, however, no comprehensive picture was available up to now.

Results

To better understand the D. discoideum response to hyperosmotic conditions, we performed gene expression profiling using DNA microarrays. The transcriptional profi

SUBMITTER: Na J 

PROVIDER: S-EPMC1888708 | biostudies-literature | 2007 May

REPOSITORIES: biostudies-literature