Side effects of phenobarbital and carbamazepine in childhood epilepsy: randomised controlled trial.

ABSTRACT:

Objective

To compare the behavioural side effects associated with two commonly used antiepilepsy drugs-phenobarbital and carbamazepine-in children in Bangladesh.

Design

Prospective randomised controlled single centre trial.

Setting

Specialist children's hospital in Dhaka, Bangladesh.

Participants

108 children aged 2-15 with generalised tonic-clonic (n=51) or partial and secondary generalised seizures (n=57).

Main outcome measures

Seizure control and behavioural side effects.

Results

91 children were followed up for 12 months. Six required a change of antiepilepsy drug. Side effects were compared in 85 children. In the last quarter of the 12 month follow-up, 71 children were seizure free after one year's treatment. Thirty two in the phenobarbital g

SUBMITTER: Banu SH 

PROVIDER: S-EPMC1889987 | biostudies-literature | 2007 Jun

REPOSITORIES: biostudies-literature