Global gene expression analysis of the mouse colonic mucosa treated with azoxymethane and dextran sodium sulfate.

ABSTRACT:

Background

Chronic inflammation is well known to be a risk factor for colon cancer. Previously we established a novel mouse model of inflammation-related colon carcinogenesis, which is useful to examine the involvement of inflammation in colon carcinogenesis. To shed light on the alterations in global gene expression in the background of inflammation-related colon cancer and gain further insights into the molecular mechanisms underlying inflammation-related colon carcinogenesis, we conducted a comprehensive DNA microarray analysis using our model.

Methods

Male ICR mice were given a single ip injection of azoxymethane (AOM, 10 mg/kg body weight), followed by the addition of 2% (w/v) dextran sodium sulfate (DSS) to their drinking water for 7 days, starting 1 week after the AOM

SUBMITTER: Suzuki R 

PROVIDER: S-EPMC1890554 | biostudies-literature | 2007 May

REPOSITORIES: biostudies-literature