Erythropoietin blockade inhibits the induction of tumor angiogenesis and progression.

ABSTRACT:

Background

The induction of tumor angiogenesis, a pathologic process critical for tumor progression, is mediated by multiple regulatory factors released by tumor and host cells. We investigated the role of the hematopoietic cytokine erythropoietin as an angiogenic factor that modulates tumor progression.

Methodology/principal findings

Fluorescently-labeled rodent mammary carcinoma cells were injected into dorsal skin-fold window chambers in mice, an angiogenesis model that allows direct, non-invasive, serial visualization and real-time assessment of tumor cells and neovascularization simultaneously using intravital microscopy and computerized image analysis during the initial stages of tumorigenesis. Erythropoietin or its antagonist proteins were co-injected with tumor cells

SUBMITTER: Hardee ME 

PROVIDER: S-EPMC1891087 | biostudies-literature | 2007 Jun

REPOSITORIES: biostudies-literature