Ontology highlight
ABSTRACT:
SUBMITTER: Mani SA
PROVIDER: S-EPMC1891217 | biostudies-literature | 2007 Jun
REPOSITORIES: biostudies-literature
Mani Sendurai A SA Yang Jing J Brooks Mary M Schwaninger Gunda G Zhou Alicia A Miura Naoyuki N Kutok Jeffery L JL Hartwell Kimberly K Richardson Andrea L AL Weinberg Robert A RA
Proceedings of the National Academy of Sciences of the United States of America 20070530 24
The metastatic spread of epithelial cancer cells from the primary tumor to distant organs mimics the cell migrations that occur during embryogenesis. Using gene expression profiling, we have found that the FOXC2 transcription factor, which is involved in specifying mesenchymal cell fate during embryogenesis, is associated with the metastatic capabilities of cancer cells. FOXC2 expression is required for the ability of murine mammary carcinoma cells to metastasize to the lung, and overexpression ...[more]