Identifying pattern-defined regulatory islands in mammalian genomes.

ABSTRACT: Identifying cis-regulatory regions in mammalian genomes is a key challenge toward understanding transcriptional regulation. However, identification and functional characterization of those regulatory elements governing differential gene expression has been hampered by the limited understanding of their organization and locations in genomes. We hypothesized that genes that are conserved across species will also display conservation at the level of their transcriptional regulation and that this will be reflected in the organization of cis-elements mediating this regulation. Using a computational approach, clusters of transcription factor binding sites that are absolutely conserved in order and in spacing across human, rat, and mouse genomes were identified. We term these regions pattern-defi

SUBMITTER: Cheung TH 

PROVIDER: S-EPMC1891267 | biostudies-literature | 2007 Jun

REPOSITORIES: biostudies-literature