A worldwide phylogeography for the human X chromosome.

ABSTRACT:

Background

We reasoned that by identifying genetic markers on human X chromosome regions where recombination is rare or absent, we should be able to construct X chromosome genealogies analogous to those based on Y chromosome and mitochondrial DNA polymorphisms, with the advantage of providing information about both male and female components of the population.

Methodology/principal findings

We identified a 47 Kb interval containing an Alu insertion polymorphism (DXS225) and four microsatellites in complete linkage disequilibrium in a low recombination rate region of the long arm of the human X chromosome. This haplotype block was studied in 667 males from the HGDP-CEPH Human Genome Diversity Panel. The haplotypic diversity was highest in Africa (0.992+/-0.0025) and lowest in

SUBMITTER: Santos-Lopes SS 

PROVIDER: S-EPMC1891433 | biostudies-literature | 2007 Jun

REPOSITORIES: biostudies-literature