An open randomized comparison of gatifloxacin versus cefixime for the treatment of uncomplicated enteric fever.

ABSTRACT:

Objective

To assess the efficacy of gatifloxacin versus cefixime in the treatment of uncomplicated culture positive enteric fever.

Design

A randomized, open-label, active control trial with two parallel arms.

Setting

Emergency Room and Outpatient Clinics in Patan Hospital, Lagankhel, Lalitpur, Nepal.

Participants

Patients with clinically diagnosed uncomplicated enteric fever meeting the inclusion criteria.

Interventions

Patients were allocated to receive one of two drugs, Gatifloxacin or Cefixime. The dosages used were Gatifloxacin 10 mg/kg, given once daily for 7 days, or Cefixime 20 mg/kg/day given in two divided doses for 7 days.

Outcome measures

The primary outcome measure was fever clearance time. The secondary outcome measure was overall tre

SUBMITTER: Pandit A 

PROVIDER: S-EPMC1891439 | biostudies-literature | 2007 Jun

REPOSITORIES: biostudies-literature