Expression profiling of renal epithelial neoplasms: a method for tumor classification and discovery of diagnostic molecular markers.

ABSTRACT: The expression patterns of 7075 genes were analyzed in four conventional (clear cell) renal cell carcinomas (RCC), one chromophobe RCC, and two oncocytomas using cDNA microarrays. Expression profiles were compared among tumors using various clustering algorithms, thereby separating the tumors into two categories consistent with corresponding histopathological diagnoses. Specifically, conventional RCCs were distinguished from chromophobe RCC/oncocytomas based on large-scale gene expression patterns. Chromophobe RCC/oncocytomas displayed similar expression profiles, including genes involved with oxidative phosphorylation and genes expressed normally by distal nephron, consistent with the mitochondrion-rich morphology of these tumors and the theory that both lesions are related histogenetical

SUBMITTER: Young AN 

PROVIDER: S-EPMC1891957 | biostudies-literature | 2001 May

REPOSITORIES: biostudies-literature