Cis- and trans-acting elements regulate the mouse Psmb9 meiotic recombination hotspot.

ABSTRACT: In most eukaryotes, the prophase of the first meiotic division is characterized by a high level of homologous recombination between homologous chromosomes. Recombination events are not distributed evenly within the genome, but vary both locally and at large scale. Locally, most recombination events are clustered in short intervals (a few kilobases) called hotspots, separated by large intervening regions with no or very little recombination. Despite the importance of regulating both the frequency and the distribution of recombination events, the genetic factors controlling the activity of the recombination hotspots in mammals are still poorly understood. We previously characterized a recombination hotspot located close to the Psmb9 gene in the mouse major histocompatibility complex by sperm

SUBMITTER: Baudat F 

PROVIDER: S-EPMC1892046 | biostudies-literature | 2007 Jun

REPOSITORIES: biostudies-literature