Identical allelic losses in mature teratoma and other histologic components of malignant mixed germ cell tumors of the testis.

ABSTRACT: Teratomas of the testis in post-pubertal patients are histologically diverse tumors that often coexist with other types of germ cell tumors. Using laser capture microdissection and loss of heterozygosity analysis, we investigated the clonality of mature teratoma and its relationship to other components of malignant mixed germ cell tumors to gain potential insight into the histogenetic relationship of teratoma with other germ cell tumor components. All 16 patients had mature teratoma as one component of their mixed germ cell tumors. The other histological subtypes included immature teratoma, seminoma, embryonal carcinoma, yolk sac tumor, and choriocarcinoma. Laser-assisted microdissection was performed on the formalin-fixed, paraffin-embedded tissue. Polymerase chain reaction was used to am

SUBMITTER: Kernek KM 

PROVIDER: S-EPMC1892383 | biostudies-literature | 2003 Dec

REPOSITORIES: biostudies-literature