Gene expression profiles in normal and Otx2-/- early gastrulating mouse embryos.

ABSTRACT: The mouse Otx2 gene is a homeobox transcription factor required as early as gastrulation for the proper development of the head. We compared gene expression profiles in wild-type and Otx2(-/-) 6.5 days postcoitum embryos by using a serial analysis of gene expression assay adapted to microdissected structures. Among a broader list, the study of six genes found to be differentially expressed allows defining a role for Otx2 in the orchestration of cell movements leading to the adequate organization of the embryo before gastrulation.

SUBMITTER: Zakin L 

PROVIDER: S-EPMC18928 | biostudies-literature | 2000 Dec

REPOSITORIES: biostudies-literature