Genome-wide diversity and selective pressure in the human rhinovirus.

ABSTRACT:

Background

The human rhinoviruses (HRV) are one of the most common and diverse respiratory pathogens of humans. Over 100 distinct HRV serotypes are known, yet only 6 genomes are available. Due to the paucity of HRV genome sequence, little is known about the genetic diversity within HRV or the forces driving this diversity. Previous comparative genome sequence analyses indicate that recombination drives diversification in multiple genera of the picornavirus family, yet it remains unclear if this holds for HRV.

Results

To resolve this and gain insight into the forces driving diversification in HRV, we generated a representative set of 34 fully sequenced HRVs. Analysis of these genomes shows consistent phylogenies across the genome, conserved non-coding elements, and only limit

SUBMITTER: Kistler AL 

PROVIDER: S-EPMC1892812 | biostudies-literature | 2007 May

REPOSITORIES: biostudies-literature