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Thiols in nitric oxide synthase-containing Nocardia sp. strain NRRL 5646.

ABSTRACT: Mycothiol (MSH) [1-D-myo-inosityl-2-(N-acetyl-l-cysteinyl)amido-2-deoxy-alpha-D-glucopyranoside], isolated as the bimane derivative, was established to be the major thiol in Nocardia sp. strain NRRL 5646, a species most closely related to Nocardia brasiliensis strain DSM 43758(T). Thiol formation and detection of MSH-dependent formaldehyde dehydrogenase activity in cell extracts are relevant to the possible modulation of nitric oxide toxicity generated by strain NRRL 5646.

SUBMITTER: Lee S 

PROVIDER: S-EPMC1892879 | biostudies-literature | 2007 May

REPOSITORIES: biostudies-literature

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Thiols in nitric oxide synthase-containing Nocardia sp. strain NRRL 5646.

Lee Sungwon S   Bergeron Hélène H   Lau Peter C K PC   Rosazza John P N JP  

Applied and environmental microbiology 20070302 9

Mycothiol (MSH) [1-D-myo-inosityl-2-(N-acetyl-l-cysteinyl)amido-2-deoxy-alpha-D-glucopyranoside], isolated as the bimane derivative, was established to be the major thiol in Nocardia sp. strain NRRL 5646, a species most closely related to Nocardia brasiliensis strain DSM 43758(T). Thiol formation and detection of MSH-dependent formaldehyde dehydrogenase activity in cell extracts are relevant to the possible modulation of nitric oxide toxicity generated by strain NRRL 5646. ...[more]

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