Increasing NADH oxidation reduces overflow metabolism in Saccharomyces cerevisiae.

ABSTRACT: Respiratory metabolism plays an important role in energy production in the form of ATP in all aerobically growing cells. However, a limitation in respiratory capacity results in overflow metabolism, leading to the formation of byproducts, a phenomenon known as "overflow metabolism" or "the Crabtree effect." The yeast Saccharomyces cerevisiae has served as an important model organism for studying the Crabtree effect. When subjected to increasing glycolytic fluxes under aerobic conditions, there is a threshold value of the glucose uptake rate at which the metabolism shifts from purely respiratory to mixed respiratory and fermentative. It is well known that glucose repression of respiratory pathways occurs at high glycolytic fluxes, resulting in a decrease in respiratory capacity. Despite man

SUBMITTER: Vemuri GN 

PROVIDER: S-EPMC1892921 | biostudies-literature | 2007 Feb

REPOSITORIES: biostudies-literature