Retrotransposons influence the mouse transcriptome: implication for the divergence of genetic traits.

ABSTRACT: Massive accumulation of retrotransposons, comprising >40% of human and mouse genomes, is one of the major events in the evolution of the genome. However, most retrotransposons have lost retrotransposition competency, which makes studying their role in genome evolution elusive. Intracisternal A-particle (IAP) elements are long terminal repeat (LTR)-type mouse retrotransposons consisting of full-length and internally deleted types. Some are retrotransposition competent and their upregulated activity has been reported in mutant mice deficient in genome defense systems, suggesting that IAP elements provide a unique platform for studying the interaction between retrotransposons and mammalian genomes. Using the IAP element as a model case, here we show that mobilization of retrotransposons alter

SUBMITTER: Horie K 

PROVIDER: S-EPMC1894610 | biostudies-literature | 2007 Jun

REPOSITORIES: biostudies-literature