Histone acetylation is associated with differential gene expression in the rapid and robust memory CD8(+) T-cell response.

ABSTRACT: To understand the molecular basis for the rapid and robust memory T-cell responses, we examined gene expression and chromatin modification by histone H3 lysine 9 (H3K9) acetylation in resting and activated human naive and memory CD8(+) T cells. We found that, although overall gene expression patterns were similar, a number of genes are differentially expressed in either memory or naive cells in their resting and activated states. To further elucidate the basis for differential gene expression, we assessed the role of histone H3K9 acetylation in differential gene expression. Strikingly, higher H3K9 acetylation levels were detected in resting memory cells, prior to their activation, for those genes that were differentially expressed following activation, indicating that hyperacetylation of h

SUBMITTER: Fann M 

PROVIDER: S-EPMC1895425 | biostudies-literature | 2006 Nov

REPOSITORIES: biostudies-literature