Endothelial protein C receptor (CD201) explicitly identifies hematopoietic stem cells in murine bone marrow.

ABSTRACT: The hematopoietic stem cell (HSC) is a unique cell type found in bone marrow, which has the capacity for both self-renewal and differentiation into all blood lineages. The identification of genes expressed specifically in HSCs may help identify gene products vital to the control of self-renewal and/or differentiation, as well as antigens capable of forming the basis for improved methods of stem cell isolation. In previous studies, we identified a number of genes that appeared to be differentially expressed in murine bone marrow-derived HSCs, using microarray technology. We report here that one of those genes, encoding the murine endothelial protein C receptor (EPCR), is expressed at high levels within the bone marrow in HSCs. Bone marrow cells isolated on the basis of EPCR expression alone

SUBMITTER: Balazs AB 

PROVIDER: S-EPMC1895725 | biostudies-literature | 2006 Mar

REPOSITORIES: biostudies-literature