Comprehensive expression profiling of tumor cell lines identifies molecular signatures of melanoma progression.

ABSTRACT:

Background

Gene expression profiling has revolutionized our ability to molecularly classify primary human tumors and significantly enhanced the development of novel tumor markers and therapies; however, progress in the diagnosis and treatment of melanoma over the past 3 decades has been limited, and there is currently no approved therapy that significantly extends lifespan in patients with advanced disease. Profiling studies of melanoma to date have been inconsistent due to the heterogeneous nature of this malignancy and the limited availability of informative tissue specimens from early stages of disease.

Methodology/principle findings

In order to gain an improved understanding of the molecular basis of melanoma progression, we have compared gene expression profiles from a

SUBMITTER: Ryu B 

PROVIDER: S-EPMC1895889 | biostudies-literature | 2007 Jul

REPOSITORIES: biostudies-literature