Comparative analysis indicates regulatory neofunctionalization of yeast duplicates.

ABSTRACT:

Background

Gene duplication provides raw material for the generation of new functions, but most duplicates are rapidly lost due to the initial redundancy in gene function. How gene function diversifies following duplication is largely unclear. Previous studies analyzed the diversification of duplicates by characterizing their coding sequence divergence. However, functional divergence can also be attributed to changes in regulatory properties, such as protein localization or expression, which require only minor changes in gene sequence.

Results

We developed a novel method to compare expression profiles from different organisms and applied it to analyze the expression divergence of yeast duplicated genes. The expression profiles of Saccharomyces cerevisiae duplicate pairs were

SUBMITTER: Tirosh I 

PROVIDER: S-EPMC1895995 | biostudies-literature | 2007

REPOSITORIES: biostudies-literature