Evolution of protein complexes by duplication of homomeric interactions.

ABSTRACT:

Background

Cellular functions are accomplished by the concerted actions of functional modules. The mechanisms driving the emergence and evolution of these modules are still unclear. Here we investigate the evolutionary origins of protein complexes, modules in physical protein-protein interaction networks.

Results

We studied protein complexes in Saccharomyces cerevisiae, complexes of known three-dimensional structure in the Protein Data Bank and clusters of pairwise protein interactions in the networks of several organisms. We found that duplication of homomeric interactions, a large class of protein interactions, frequently results in the formation of complexes of paralogous proteins. This route is a common mechanism for the evolution of complexes and clusters of protein int

SUBMITTER: Pereira-Leal JB 

PROVIDER: S-EPMC1895999 | biostudies-literature | 2007

REPOSITORIES: biostudies-literature