Fibrinogen gamma-A chain precursor in CSF: a candidate biomarker for Alzheimer's disease.

ABSTRACT:

Background

Cerebrospinal fluid (CSF) may be valuable for exploring protein markers for the diagnosis of Alzheimer's disease (AD). The prospect of early detection and treatment, to slow progression, holds hope for aging populations with increased average lifespan. The aim of the present study was to investigate candidate CSF biological markers in patients with mild cognitive impairment (MCI) and AD and compare them with age-matched normal control subjects.

Methods

We applied proteomics approaches to analyze CSF samples derived from 27 patients with AD, 3 subjects with MCI and 30 controls. The AD group was subdivided into three groups by clinical severity according to clinical dementia rating (CDR), a well known clinical scale for dementia.

Results

We demonstrated an el

SUBMITTER: Lee JW 

PROVIDER: S-EPMC1896177 | biostudies-literature | 2007 Jun

REPOSITORIES: biostudies-literature