Synaptophysin I selectively specifies the exocytic pathway of synaptobrevin 2/VAMP2.

ABSTRACT: Biogenesis and recycling of synaptic vesicles are accompanied by sorting processes that preserve the molecular composition of the compartments involved. In the present study, we have addressed the targeting of synaptobrevin 2/VAMP2 (vesicle-associated membrane protein 2), a critical component of the synaptic vesicle--fusion machinery, in a heterotypic context where its sorting is not confounded by the presence of other neuron-specific molecules. Ectopically expressed synaptophysin I interacts with VAMP2 and alters its default surface targeting to a prominent vesicular distribution, with no effect on the targeting of other membrane proteins. Protein-protein interaction is not sufficient for the control of VAMP2 sorting, which is mediated by the C-terminal domain of synaptophysin I. Synaptop

SUBMITTER: Bonanomi D 

PROVIDER: S-EPMC1896278 | biostudies-literature | 2007 Jun

REPOSITORIES: biostudies-literature