Characterization of the genomic region containing the Shadow of Prion Protein (SPRN) gene in sheep.

ABSTRACT:

Background

TSEs are a group of fatal neurodegenerative diseases occurring in man and animals. They are caused by prions, alternatively folded forms of the endogenous prion protein, encoded by PRNP. Since differences in the sequence of PRNP can not explain all variation in TSE susceptibility, there is growing interest in other genes that might have an influence on this susceptibility. One of these genes is SPRN, a gene coding for a protein showing remarkable similarities with the prion protein. Until now, SPRN has not been described in sheep, a highly relevant species in prion matters.

Results

In order to characterize the genomic region containing SPRN in sheep, a BAC mini-contig was built, covering approximately 200,000 bp and containing the genes ECHS1, PAOX, MTG1, SPRN, LO

SUBMITTER: Lampo E 

PROVIDER: S-EPMC1899180 | biostudies-literature | 2007 May

REPOSITORIES: biostudies-literature