Combination therapy with a long-acting beta-agonist and a leukotriene antagonist in moderate asthma.

ABSTRACT:

Rationale

Long-acting beta-agonists (LABAs) and inhaled corticosteroids administered together appear to be complementary in terms of effects on asthma control. The elements of asthma control achieved by LABAs (improved lung function) and leukotriene receptor antagonists (LTRAs; protection against exacerbations) may be complementary as well.

Objective

We sought to determine whether the combination of the LTRA montelukast and the LABA salmeterol could provide an effective therapeutic strategy for asthma.

Methods and measurements

In a randomized, placebo-controlled, crossover study of 192 subjects with moderate asthma, we compared the clinical efficacy of regular treatment over 14 weeks with the combination of montelukast and salmeterol to that with the combination of be

SUBMITTER: Deykin A 

PROVIDER: S-EPMC1899264 | biostudies-literature | 2007 Feb

REPOSITORIES: biostudies-literature