The role of CC chemokine receptor 6 in host defense in a model of invasive pulmonary aspergillosis.

ABSTRACT:

Rationale

Invasive aspergillosis is a severe fungal infection afflicting immunocompromised patients, particularly patients with neutrophil defects. CCR6, a beta-chemokine receptor, mediates migration of dendritic cells (DCs) and several lymphocyte subsets to sites of epithelial inflammation, but its role in infections has not been examined extensively.

Objectives

To test the hypothesis that CCR6-mediated leukocyte recruitment is necessary for effective host defense in neutropenic hosts with invasive pulmonary aspergillosis.

Methods

Neutropenic wild-type mice and mice with targeted deletion of CCR6 were infected with Aspergillus fumigatus. The host responses to the infection were compared in vivo and leukocyte responses to the fungus were examined in vitro.

Measurem

SUBMITTER: Phadke AP 

PROVIDER: S-EPMC1899275 | biostudies-literature | 2007 Jun

REPOSITORIES: biostudies-literature