Coagulation factor Xa modulates airway remodeling in a murine model of asthma.

ABSTRACT:

Rationale

Previous studies have demonstrated that dysregulated coagulation and fibrinolysis contribute to the pathogenesis of asthma.

Objective

The role of procoagulant factor X in a murine model of ovalbumin (OVA)-induced asthma was investigated.

Methods

Biochemical, cellular, and physiologic in vivo and in vitro approaches were used to determine effects of factor X on the asthmatic response in mice.

Measurements and main results

Factor X transcript levels and factor Xa activity were increased in lungs of asthmatic mice challenged with OVA, compared with controls treated with phosphate-buffered saline. Factor X was highly expressed in bronchoalveolar lavage fluid macrophages from asthmatic mice. Treatment of mice with the factor Xa inhibitor fondaparinux durin

SUBMITTER: Shinagawa K 

PROVIDER: S-EPMC1899277 | biostudies-literature | 2007 Jan

REPOSITORIES: biostudies-literature