Secreted modular calcium-binding protein 2 haplotypes are associated with pulmonary function.

ABSTRACT:

Rationale

Previously reported linkage to FEV(1) (LOD score = 5.0) on 6q27 in the Framingham Heart Study (FHS) led us to explore a candidate gene, SMOC2, at 168.6 Mb.

Objectives

We tested association between SMOC2 polymorphisms and FEV(1) and FVC in unrelated FHS participants.

Methods

Twenty single-nucleotide polymorphisms (SNPs) around SMOC2 were genotyped in 1,734 subjects.

Measurements and main results

SNP data were analyzed using multiple linear regression models incorporating sex, age, body mass index, height, and smoking history as covariates, and analyses were repeated within strata of ever- and never-smokers. The minor allele of SNP rs1402 was associated with higher mean FEV(1) (p = 0.003) and FVC (p = 0.02) measures. In never-smoking subjects, associati

SUBMITTER: Wilk JB 

PROVIDER: S-EPMC1899283 | biostudies-literature | 2007 Mar

REPOSITORIES: biostudies-literature