Leptin resistance protects mice from hyperoxia-induced acute lung injury.

ABSTRACT:

Rationale

Human data suggest that the incidence of acute lung injury is reduced in patients with type II diabetes mellitus. However, the mechanisms by which diabetes confers protection from lung injury are unknown.

Objectives

To determine whether leptin resistance, which is seen in humans with diabetes, protects mice from hyperoxic lung injury.

Methods

Wild-type (leptin responsive) and db/db (leptin resistant) mice were used in these studies. Mice were exposed to hyperoxia (100% O(2)) for 84 hours to induce lung injury and up to 168 hours for survival studies. Alveolar fluid clearance was measured in vivo.

Measurements and main results

Lung leptin levels were increased both in wild-type and leptin receptor-defective db/db mice after hyperoxia. Hyperoxia-induced

SUBMITTER: Bellmeyer A 

PROVIDER: S-EPMC1899284 | biostudies-literature | 2007 Mar

REPOSITORIES: biostudies-literature