Airway hyperresponsiveness in allergically inflamed mice: the role of airway closure.

ABSTRACT:

Rationale

Allergically inflamed mice exhibit airway hyperresponsiveness to inhaled methacholine, which computer simulations of lung impedance suggest is due to enhanced lung derecruitment and which we sought to verify in the present study.

Methods

BALB/c mice were sensitized and challenged with ovalbumin to induce allergic inflammation; the control mice were sensitized but received no challenge. The mice were then challenged with inhaled methacholine and respiratory system impedance tracked for the following 10 minutes. Respiratory elastance (H) was estimated from each impedance measurement. One group of mice was ventilated with 100% O(2) during this procedure and another group was ventilated with air. After the procedure, the mice were killed and ventilated with pure N(2),

SUBMITTER: Lundblad LK 

PROVIDER: S-EPMC1899295 | biostudies-literature | 2007 Apr

REPOSITORIES: biostudies-literature