Conservation of the links between gene transcription and chromosomal organization in the highly reduced genome of Buchnera aphidicola.

ABSTRACT:

Background

Genomic studies on bacteria have clearly shown the existence of chromosomal organization as regards, for example, to gene localization, order and orientation. Moreover, transcriptomic analyses have demonstrated that, in free-living bacteria, gene transcription levels and chromosomal organization are mutually influenced. We have explored the possible conservation of relationships between mRNA abundances and chromosomal organization in the highly reduced genome of Buchnera aphidicola, the primary endosymbiont of the aphids, and a close relative to Escherichia coli.

Results

Using an oligonucleotide-based microarray, we normalized the transcriptomic data by genomic DNA signals in order to have access to inter-gene comparison data. Our analysis showed that mRNA abundan

SUBMITTER: Vinuelas J 

PROVIDER: S-EPMC1899503 | biostudies-literature | 2007 Jun

REPOSITORIES: biostudies-literature