The three-dimensional structure of human interphase chromosomes is related to the transcriptome map.

ABSTRACT: The three-dimensional (3D) organization of the chromosomal fiber in the human interphase nucleus is an important but poorly understood aspect of gene regulation. Here we quantitatively analyze and compare the 3D structures of two types of genomic domains as defined by the human transcriptome map. While ridges are gene dense and show high expression levels, antiridges, on the other hand, are gene poor and carry genes that are expressed at low levels. We show that ridges are in general less condensed, more irregularly shaped, and located more closely to the nuclear center than antiridges. Six human cell lines that display different gene expression patterns and karyotypes share these structural parameters of chromatin. This shows that the chromatin structures of these two types of genomic dom

SUBMITTER: Goetze S 

PROVIDER: S-EPMC1900058 | biostudies-literature | 2007 Jun

REPOSITORIES: biostudies-literature