Human T-cell leukemia virus type 1 integration target sites in the human genome: comparison with those of other retroviruses.

ABSTRACT: Retroviral integration into the host genome is not entirely random, and integration site preferences vary among different retroviruses. Human immunodeficiency virus (HIV) prefers to integrate within active genes, whereas murine leukemia virus (MLV) prefers to integrate near transcription start sites and CpG islands. On the other hand, integration of avian sarcoma-leukosis virus (ASLV) shows little preference either for genes, transcription start sites, or CpG islands. While host cellular factors play important roles in target site selection, the viral integrase is probably the major viral determinant. It is reasonable to hypothesize that retroviruses with similar integrases have similar preferences for target site selection. Although integration profiles are well defined for members of the

SUBMITTER: Derse D 

PROVIDER: S-EPMC1900082 | biostudies-literature | 2007 Jun

REPOSITORIES: biostudies-literature