Characterization of microRNA expression profiles in normal human tissues.

ABSTRACT:

Background

Measuring the quantity of miRNAs in tissues of different physiological and pathological conditions is an important first step to investigate the functions of miRNAs. Matched samples from normal state can provide essential baseline references to analyze the variation of miRNA abundance.

Results

We provided expression data of 345 miRNAs in 40 normal human tissues, which identified universally expressed miRNAs, and several groups of miRNAs expressed exclusively or preferentially in certain tissue types. Many miRNAs with co-regulated expression patterns are located within the same genomic clusters, and candidate transcriptional factors that control the pattern of their expression may be identified by a comparative genomic strategy. Hierarchical clustering of normal ti

SUBMITTER: Liang Y 

PROVIDER: S-EPMC1904203 | biostudies-literature | 2007 Jun

REPOSITORIES: biostudies-literature