High resolution crystal structure of PedB: a structural basis for the classification of pediocin-like immunity proteins.

ABSTRACT:

Background

Pediocin-like bacteriocins, ribosomally-synthesized antimicrobial peptides, are generally coexpressed with cognate immunity proteins in order to protect the bacteriocin-producer from its own bacteriocin. As a step for understanding the mode of action of immunity proteins, we determined the crystal structure of PedB, a pediocin-like immunity protein conferring immunity to pediocin PP-1.

Results

The 1.6 A crystal structure of PedB reveals that PedB consists of an antiparallel four-helix bundle with a flexible C-terminal end. PedB shows structural similarity to an immunity protein against enterocin A (EntA-im) but some disparity to an immunity protein against carnobacteriocin B2 (ImB2) in both the C-terminal conformation and the local structure constructed by alpha3,

SUBMITTER: Kim IK 

PROVIDER: S-EPMC1904221 | biostudies-literature | 2007 May

REPOSITORIES: biostudies-literature