Cross-study analysis of gene expression data for intermediate neuroblastoma identifies two biological subtypes.

ABSTRACT:

Background

Neuroblastoma patients show heterogeneous clinical courses ranging from life-threatening progression to spontaneous regression. Recently, gene expression profiles of neuroblastoma tumours were associated with clinically different phenotypes. However, such data is still rare for important patient subgroups, such as patients with MYCN non-amplified advanced stage disease. Prediction of the individual course of disease and optimal therapy selection in this cohort is challenging. Additional research effort is needed to describe the patterns of gene expression in this cohort and to identify reliable prognostic markers for this subset of patients.

Methods

We combined gene expression data from two studies in a meta-analysis in order to investigate differences in gene exp

SUBMITTER: Warnat P 

PROVIDER: S-EPMC1904223 | biostudies-literature | 2007 May

REPOSITORIES: biostudies-literature