Phenotype frequencies of autosomal minor histocompatibility antigens display significant differences among populations.

ABSTRACT: Minor histocompatibility (H) antigens are allogeneic target molecules having significant roles in alloimmune responses after human leukocyte antigen-matched solid organ and stem cell transplantation (SCT). Minor H antigens are instrumental in the processes of transplant rejection, graft-versus-host disease, and in the curative graft-versus-tumor effect of SCT. The latter characteristic enabled the current application of selected minor H antigens in clinical immunotherapeutic SCT protocols. No information exists on the global phenotypic distribution of the currently identified minor H antigens. Therefore, an estimation of their overall impact in human leukocyte antigen-matched solid organ and SCT in the major ethnic populations is still lacking. For the first time, a worldwide phenotype fre

SUBMITTER: Spierings E 

PROVIDER: S-EPMC1904367 | biostudies-literature | 2007 Jun

REPOSITORIES: biostudies-literature