Common molecular pathways involved in human CD133+/CD34+ progenitor cell expansion and cancer.

ABSTRACT:

Background

Uncovering the molecular mechanism underlying expansion of hematopoietic stem and progenitor cells is critical to extend current therapeutic applications and to understand how its deregulation relates to leukemia. The characterization of genes commonly relevant to stem/progenitor cell expansion and tumor development should facilitate the identification of novel therapeutic targets in cancer.

Methods

CD34+/CD133+ progenitor cells were purified from human umbilical cord blood and expanded in vitro. Correlated molecular changes were analyzed by gene expression profiling using microarrays covering up to 55,000 transcripts. Genes regulated during progenitor cell expansion were identified and functionally classified. Aberrant expression of such genes in cancer was indic

SUBMITTER: Okamoto OK 

PROVIDER: S-EPMC1904434 | biostudies-literature | 2007 Jun

REPOSITORIES: biostudies-literature