Evidence of differential HLA class I-mediated viral evolution in functional and accessory/regulatory genes of HIV-1.

ABSTRACT: Despite the formidable mutational capacity and sequence diversity of HIV-1, evidence suggests that viral evolution in response to specific selective pressures follows generally predictable mutational pathways. Population-based analyses of clinically derived HIV sequences may be used to identify immune escape mutations in viral genes; however, prior attempts to identify such mutations have been complicated by the inability to discriminate active immune selection from virus founder effects. Furthermore, the association between mutations arising under in vivo immune selection and disease progression for highly variable pathogens such as HIV-1 remains incompletely understood. We applied a viral lineage-corrected analytical method to investigate HLA class I-associated sequence imprinting in HIV

SUBMITTER: Brumme ZL 

PROVIDER: S-EPMC1904471 | biostudies-literature | 2007 Jul

REPOSITORIES: biostudies-literature