IgE expression pattern in lung: relation to systemic IgE and asthma phenotypes.

ABSTRACT:

Background

IgE-mediated responses contribute to allergy and asthma. Little is understood regarding the relationship of tissue IgE to systemic IgE, inflammation or clinical outcomes.

Objectives

To evaluate local IgE expression and cellular inflammation in the proximal and distal lung of normal subjects and subjects with asthma of varying severity and relate those tissue parameters to systemic IgE levels, atopy, lung function, and history of severe exacerbations of asthma.

Methods

Tissue from more than 90 subjects with eosinophilic (SAeo(+)) and noneosinophilic (SAeo(-)) severe asthma, mild asthma and normal subjects were immunostained for IgE, signal-amplifying isoform of IgE receptor (FcepsilonRIbeta) and markers of mast cells, eosinophils, and lymphocytes. Tissue exp

SUBMITTER: Balzar S 

PROVIDER: S-EPMC1905834 | biostudies-literature | 2007 Apr

REPOSITORIES: biostudies-literature