Intraflagellar transport protein 27 is a small G protein involved in cell-cycle control.

ABSTRACT:

Background

Intraflagellar transport (IFT) is a motility process operating between the ciliary/flagellar (interchangeable terms) membrane and the microtubular axoneme of motile and sensory cilia. Multipolypeptide IFT particles, composed of complexes A and B, carry flagellar precursors to their assembly site at the flagellar tip (anterograde) powered by kinesin, and turnover products from the tip back to the cytoplasm (retrograde) driven by cytoplasmic dynein. IFT is essential for the assembly and maintenance of almost all eukaryotic cilia and flagella, and mutations affecting either the IFT motors or the IFT particle polypeptides result in the inability to assemble normal flagella or in defects in the sensory functions of cilia.

Results

We found that the IFT complex B polypep

SUBMITTER: Qin H 

PROVIDER: S-EPMC1905864 | biostudies-literature | 2007 Feb

REPOSITORIES: biostudies-literature