ZPS: visualization of recent adaptive evolution of proteins.

ABSTRACT:

Background

Detection of adaptive amino acid changes in proteins under recent short-term selection is of great interest for researchers studying microevolutionary processes in microbial pathogens or any other biological species. However, independent occurrence of such point mutations within genetically diverse haplotypes makes it difficult to detect the selection footprint by using traditional molecular evolutionary analyses. The recently developed Zonal Phylogeny (ZP) has been shown to be a useful analytic tool for identifying the footprints of short-term positive selection. ZP separates protein-encoding genes into evolutionarily long-term (with silent diversity) and short-term (without silent diversity) categories, or zones, followed by statistical analysis to detect signs of posi

SUBMITTER: Chattopadhyay S 

PROVIDER: S-EPMC1905921 | biostudies-literature | 2007 Jun

REPOSITORIES: biostudies-literature