Polymorphisms cMyc-N11S and p27-V109G and breast cancer risk and prognosis.

ABSTRACT:

Background

cMyc and p27 are key genes implicated in carcinogenesis. Whether polymorphisms in these genes affect breast cancer risk or prognosis is still unclear. In this study, we focus on a rare non-synonymous polymorphism in cMyc (N11S) and a common polymorphism in p27 (V109G) and determine their role in risk and prognosis using data collected from the Ontario Breast Cancer Family Registry.

Methods

Risk factor data was collected at baseline on a large group of women (cases = 1,115 and population-based controls = 710) and clinical data (including treatment and follow-up) were collected prospectively by periodic review of medical records for a subset of cases (N = 967) for nearly a decade. A centralized pathology review was conducted. Unconditional logistic regression was us

SUBMITTER: Figueiredo JC 

PROVIDER: S-EPMC1906827 | biostudies-literature | 2007 Jun

REPOSITORIES: biostudies-literature